NACSELD 1

Determine the prognosis of inpatients with cirrhosis and infections.

Steering Committee

Jasmohan S Bajaj, MD

Virginia Commonwealth University, Richmond, VA
K Rajender Reddy, MD

University of Pennsylvania, Philadelphia, PA, USA
Jacqueline G O’leary, MD

Baylor University Medical Center, Dallas, TX, USA
Florence Wong, MD

University of Toronto, Toronto, Canada
Guadalupe Garcia-Tsao, MD

Yale University, New Haven, CT, USA
Patrick S Kamath

Mayo Clinic, Rochester, MN, USA

Participating Sites & PIs

University of Alberta, Edmonton, Canada

Puneeta Tandon, MD
University of Rochester, Rochester, NY

Benedict Maliakkal, MD
University of Colorado, Denver, CO

Scott W Biggins
University of Texas, Houston, TX

Michael Fallon
Mercy Medical Center, Baltimore, MD

Paul Thuluvath
University of San Diego, San Diego, CA

Heather Patton
Beth Israel Deaconess MC, Boston, MA

Raza Malik
Emory University, Atlanta, GA

Ram Subramanian
University of California, San Francisco, CA

Jennifer C Lai, MD
Mayo Clinic, Phoenix, AZ

Hugo E Vargas, MD

Data & Biorepository

VCU Data Coordinating Center, Richmond, VA

Centralized Study set up at Richmond Institute for Veterans Research, Richmond, VA

Consortium
Publications

O'Leary J.G, Reddy KR, Garcia-Tsao G, Biggins SW, Wong F, Fallon MB, Subramanian RM, Kamath PS, Thuluvath P, Vargas HE, Maliakkal B, Tandon P, Lai Jennifer, Thacker LR, Bajaj JS
Hepatology 2018 doi: 10.1002/hep.29773

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Bajaj, J.S., Reddy, K.R., Tandon, P., Wong, F., Kamath, P.S., Biggins, S.W., Garcia-Tsao, G., Fallon, M.B., Maliakkal, B.J., Lai, J.C., Vargas H.E., Subramanian R.M, Thuluvath, P.J., Thacker L.R., O’Leary J.G
American Journal of Gastroenterology 2018 Dec 19. doi: 10.1038/ajg.2017.471
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Bhutta AQ, Garcia-Tsao G, Reddy KR, Tandon P, Wong F, O'Leary JG, Acharya C, Banerjee D, Abraldes JG, Jones TM, Shaw J, Deng Y, Ciarleglio M, Bajaj JS
Aliment Pharmacol Ther. 2018 Jan;47(1):78-85. doi: 10.1111/apt.14366
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Wong F, O'Leary JG, Reddy KR, Garcia-Tsao G, Fallon MB, Biggins SW, Subramanian RM, Thuluvath PJ, Kamath PS, Patton H, Maliakkal B, Tandon P, Vargas H, Thacker L, Bajaj JS
Am J Gastroenterol. 2017 Apr 25. doi: 10.1038/ajg.2017.122
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O'Leary JG, Wong F, Reddy KR, Garcia-Tsao G, Kamath PS, Biggins SW, Fallon MB, Subramanian RM, Maliakkal B, Thacker L, Bajaj JS
Dig Dis Sci. 2017 Mar;62(3):768-776

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Tandon P, Reddy KR, O'Leary JG, Garcia-Tsao G, Abraldes JG, Wong F, Biggins SW, Maliakkal B, Fallon MB, Subramanian RM, Thuluvath P, Kamath PS, Thacker LR, Bajaj JS; NACSELD: North American Consortium for the Study of End-Stage Liver Disease
Hepatology. 2016 Oct 24. doi: 10.1002/hep.28900
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Bajaj JS, O'Leary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Maliakkal B, Biggins SW, Thuluvath P, Fallon MB, Subramanian RM, Vargas HE, Lai J, Thacker LR, Reddy KR
Clin Gastroenterol Hepatol. 2016 Oct 5. pii: S1542-3565(16)30870-9. doi: 10.1016/j.cgh.2016.09.157.

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KR Reddy, JG., O'Leary, PS., Kamath, MB., Fallon, SW Biggins, F Wong, HM Patton, G Garcia-Tsao, RM Subramanian, LR Thacker, JS. Bajaj on behalf of NACSELD
Liver Transplantation 2015; 21(7): 881-8,doi: 10.1002/lt.24139

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JG O’leary, KR Reddy, F Wong, PS Kamath, H Patton, SW Biggins, MB Fallon, G Garcia-Tsao, RM Subramanian, R Malik, LR Thacker, JS Bajaj (NACSELD)

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JS Bajaj, JG O’Leary, KR Reddy, F Wong, SW Biggins, H Patton, MB Fallon, G Garcia-Tsao, B Maliakkal, R Malik, RM Subramanian, LR Thacker, PS Kamath
Hepatology 2014 Jul;60(1):250-6. doi: 10.1002/hep.27077

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F Wong, JG O’leary, KR Reddy, H Patton, RM Subramanian, PS Kamath, B Maliakkal, G Garcia-Tsao, R Malik, LR Thacker, JS Bajaj
Gastroenterology 2013 Dec;145(6):1280-1288.e1. doi: 10.1053/j.gastro.2013.08.051
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JS Bajaj, JG O’leary, KR Reddy, F Wong, JC Olson, RM Subramanian, G Brown, NA Noble, LR Thacker, PS Kamath
Hepatology 2012 Dec;56(6):2328-35

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JS Bajaj, JG O’leary, KR Reddy, F Wong, PS Kamath
Gut 2012 Aug;61(8):1219-25
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Jasmohan S Bajaj, Puneeta Tandon, Jacqueline G O’Leary, Scott W Biggins, Florence Wong, Patrick S Kamath, Guadalupe Garcia-Tsao, Benedict Maliakkal, Jennifer C. Lai, Michael Fallon, Paul Thuluvath, Hugo E. Vargas, Ram M Subramanian, Leroy R Thacker, K. Rajender Reddy
American Journal of Gastroenterology 2018 Accepted in Press
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Meeting Abstracts

Jacqueline G. O'Leary1 , K. Rajender Reddy2 , Guadalupe Garcia-Tsao3 , Scott W. Biggins4 , Florence Wong5 , Michael B. Fallon6 , Ram M. Subramanian7 , Patrick S. Kamath8 , Paul J. Thuluvath9 , Benedict Maliakkal10 , Heather Patton11 , Puneeta Tandon12 , Leroy R. Thacker13 , JS Bajaj1
DDW 2015
Florence Wong1 , Jacqueline G. O'Leary2 , K. Rajender Reddy3 , Guadalupe Garcia-Tsao4 , Michael B. Fallon5 , Scott W. Biggins6 , Ram M. Subramanian7 , Paul J. Thuluvath8 , Patrick S. Kamath9 , Heather Patton10 , Benedict Maliakkal11 , Puneeta Tandon12 , Hugo E. Vargas13 , Leroy R. Thacker14JS Bajaj1
DDW 2015
Patrick S Kamath, Jacqueline G. O’Leary, K. Rajender Reddy, Florence Wong, Siddharth Singh, Michael B Fallon, Guadalupe Garcia-Tsao, Scott Biggins, Benedict Maliakkal, Ram Subramanian, Heather Patton, Leroy R Thacker, JS Bajaj
Liver meeting 2014
JS Bajaj, J. O'leary2, K.R. Reddy3, F. Wong4, M. Fallon5, S. Biggins6, H. Patton7, B. Maliakkal8, P.Thuluvath9, G. Garcia-Tsao10, D. Koch11, L. Thacker12, P. Kamath13, North American Consortium for Study of End-Stage Liver Disease (NACSELD)
J Hepatol 2014, EASL 2014 Conference.
Biggins SW, O'Leary JG, Reddy KR, Wong F, Kamath PS, Patton HM, Fallon MB, Garcia-Tsao G, Subramanian RM, Thuluvath P, Maliakkal B
Journal of Hepatology. 2014 Apr 1;60(1):S237.
J.S. Bajaj1, J.G. O'leary2, K.R. Reddy3, J.C. Olson4, F. Wong5, G. Brown6, R. Subramanian7, R. Malik8, L.R. Thacker9, N.A. Noble1, P.S. Kamath4
AASLD Liver Meeting 2013
Wong, F., O'leary, J. G., Reddy, K. R., Patton, H., Kamath, P. S., Fallon, M. B., & Bajaj, J. S (2013)
EASL meeting Oral presentation Journal of Hepatology, 58, S37.
O'Leary, J. G., Reddy, K. R., Wong, F., Kamath, P. S., Patton, H. M., Biggins, S. W., & Bajaj, J. S. (2013)
EASL 2013 Journal of Hepatology, 58, S97.
Patton HM, O'Leary JG, Reddy R, Kamath PS, Wong F, Maliakkal B, Fallon MB, Garcia-Tsao G, Subramanian RM, Malik R, Thacker L
In HEPATOLOGY 2013 Oct 1 (Vol. 58, pp. 877A-878A).
Bajaj JS, O'Leary JG, Reddy KR, Wong F, Patton HM, Biggins SW, Maliakkal B, Fallon MB, Garcia-Tsao G, Subramanian RM, Thapar M
In HEPATOLOGY 2013 Oct 1 (Vol. 58, pp. 852A-853A).
JG. O'Leary, KR Reddy, F Wong, G Brown, RM. Subramanian, R Malik, HM Patton, SW Biggins, K Bambha, MB Fallon, L Thacker, PS. Kamath, JS Bajaj
Hepatology 2012 AASLD Annual Meeting
JS Bajaj, PS. Kamath, JG. O'Leary, KR Reddy, F Wong
Hepatology 2012 AASLD Annual Meeting
J.S. Bajaj1, J.G. O'leary2, K.R. Reddy3, J.C. Olson4, F. Wong5, G. Brown6, R. Subramanian7, R. Malik8, L.R. Thacker9, N.A. Noble1, P.S. Kamath4, North American Consortium of the Study of End-Stage Liver Disease (NACSELD)
2012 EASL International Liver Congress

Determine the prognosis of inpatients with cirrhosis and infections.

Jasmohan S Bajaj, MD

K Rajender Reddy, MD

Jacqueline G O’leary, MD

Florence Wong, MD

Guadalupe Garcia-Tsao, MD

Patrick S Kamath

University of Alberta, Edmonton, Canada

University of Rochester, Rochester, NY

University of Colorado, Denver, CO

University of Texas, Houston, TX

Mercy Medical Center, Baltimore, MD

University of San Diego, San Diego, CA

Beth Israel Deaconess MC, Boston, MA

Emory University, Atlanta, GA

University of California, San Francisco, CA

Mayo Clinic, Phoenix, AZ

VCU Data Coordinating Center, Richmond, VA

Consortium
Publications

Meeting Abstracts

NACSELD 3

NACSELD 2

NACSELD 1

Determine the prognosis of inpatients with cirrhosis and infections.

Jasmohan S Bajaj, MD

K Rajender Reddy, MD

Jacqueline G O’leary, MD

Florence Wong, MD

Guadalupe Garcia-Tsao, MD

Patrick S Kamath

University of Alberta, Edmonton, Canada

University of Rochester, Rochester, NY

University of Colorado, Denver, CO

University of Texas, Houston, TX

Mercy Medical Center, Baltimore, MD

University of San Diego, San Diego, CA

Beth Israel Deaconess MC, Boston, MA

Emory University, Atlanta, GA

University of California, San Francisco, CA

Mayo Clinic, Phoenix, AZ

VCU Data Coordinating Center, Richmond, VA

ConsortiumPublications

NACSELD Acute-on-Chronic Liver Failure (NACSELD-ACLF) Score Predicts 30-Day Survival in Hospitalized Patients with Cirrhosis

Prediction of Fungal Infection Development and Their Impact on Survival using the NACSELD Cohort

Beta-blockers in hospitalised patients with cirrhosis and ascites: mortality and factors determining discontinuation and reinitiation

Acute Kidney Injury in Cirrhosis: Baseline Serum Creatinine Predicts Patient Outcomes

Gender-Specific Differences in Baseline, Peak, and Delta Serum Creatinine: The NACSELD Experience

A Karnofsky performance status-based score predicts death after hospital discharge in patients with cirrhosis

Hepatic Encephalopathy Remains an Important Independent Determinant of Mortality in Cirrhosis: A Multi-Center NACSELD Experience

High Risk of Delisting or Death in Liver Transplant Candidates Following Infections: Results from NACSELD

Long-term use of antibiotics and proton pump inhibitors predict development of infections in patients with cirrhosis.

Survival in infection-related acute-on-chronic liver failure is defined by extra-hepatic organ failures

New Consensus Definition for Acute Kidney Injury Accurately Predicts 30-day mortality in Cirrhosis with Infection

Second infections independently increase mortality in hospitalized patients with cirrhosis: the North American consortium for the study of end-stage liver disease (NACSELD) experience.

Bacterial Infections In End Stage Liver Disease: Current Challenges, And Future Directions

The Impact of Albumin Use on Resolution of Hyponatremia in Hospitalized Patients with Cirrhosis

ACLF Prognostication: Complex ≠ Better (reply to LTE HEP-18-0338)New Item

The Impact of Albumin Use on Resolution of Hyponatremia in Hospitalized Patients With Cirrhosis

Meeting Abstracts

Validation of Infection-Related Acute-on-Chronic Liver Failure (I-ACLF) Definition for 30-Day Mortality Prediction in Infected and Uninfected Hospitalized Cirrhotic Patients

Acute kidney injury in cirrhosis: Baseline serum creatinine predicts patient outcomes

Mortality risk associated with Acute on Chronic Liver Failure varies dependent on inciting event: a NACSELD study

Differences In Creatinine Between Genders Could Disadvantage Infected Cirrhotic Women: The NACSELD Experience

P502 Spontaneous bacterial peritonitis and bacteremia predict mortality in cirrhosis despite prophylactic measures: a prospective multi-center study from nacseld

Nosocomial Index Infections Portend Worse Outcomes Compared to Health-Care Associated Index Infections in a Multi-Center Hospitalized Cirrhosis Cohort (NACSELD)

83 The new consensus definition of acute kidney injury is valid in predicting mortality in hospitalized infected cirrhotic patients: the NACSELD experience

226 Long-term antibiotic and proton-pump inhibitor use are strong predictors of recurrent infections in cirrhosis: a prospective multi-center study from NACSELD

Urinary Tract Infections are Associated with Similar Poor Outcomes Compared to Other Infections in a Multi-Center Hospitalized Cirrhosis Cohort (NACSELD)

Nosocomial Index Infections Portend Worse Outcomes Compared to Health-Care Associated Index Infections in a Multi-Center Hospitalized Cirrhosis Cohort (NACSELD)

Prior Infections Predict the Risk of Future Infections: A Prospective Multi-Center Study from the North American Consortium for the Study of End-Stage Liver Disease (NACSELD)

Multiple organ dysfunction defines Acute-on-Chronic Liver Failure: the NACSELD study

In-Hospital Mortality In Cirrhosis Is Related To Nosocomial Infections Independent Of Meld Score: The North American Consortium For The Study Of End-Stage Liver Disease (NACSELD) Study

NACSELD 3

NACSELD 2

NACSELD 1

Consortium
Publications